Invitation Card Background High Resolution – Invitation Card Background High Resolution
Fig. 1 displays the ECS test-offer and accouterment of care. By sending out an allurement letter, accommodating GPs offered all potentially acceptable women registered in their practices the befalling to booty allotment in the ECS testing program. Couples who were absorbed in the ECS assay could accomplish an arrangement for pre-test counselling with the agreeable GP. Afterwards they would adjudge whether or not to advance with testing. The ECS-test was alone attainable to couples who accustomed pre-test counselling and couples were adapted to appear pre-test counselling together.
Overview of ECS test-offer, accouterment of affliction and abstraction design.GPs provided pre-test counselling to couples absorbed in ECS testing. Subsequently, couples could adjudge to advance with testing. We acclimated a mixed-methods longitudinal abstraction in which assessments were fabricated at four time credibility (T0-T3) through either questionnaires and/or semi-structured interviews, with couples and accommodating GPs as abstraction participants
Trained GPs were asked to accommodate pre-test counselling about ECS in aggregate with accustomed assumption affliction (GPC) admonition (e.g., admonition about folic acerbic supplementation, abeyance of booze use or smoking). For this counselling, a double-consultation time was attainable (20 min). Referral to the Analytic Assay administration of the UMCG was attainable for couples articular to accept above-mentioned added risk, e.g., due to doubtable ancestors history of a abiogenetic condition. Couples who proceeded with the ECS assay could accord a claret sample application appeal forms provided by the GP. The UMCG Genomics Laboratory performed the test. With a turn-around time of 8 weeks, GPs accustomed a aftereffect for couples who provided claret samples and again announced the after-effects to them. A brace was advised a carrier brace if both brace associates accept a chic IV or V alternative in one of the backward ache genes included in the test.
Carrier couples, but additionally non-carrier couples with actual questions, could be referred to Analytic Assay for post-test counselling. We additionally launched a about attainable website with accustomed advice about the 50 AR conditions, the ECS test, and accompanying procedures (www.dragerschapstest.umcg.nl). The assay team, including the abiogenetic advocate involved, could be contacted through the website. There were no accommodating expenditures associated with the abstraction and test-participation. PGT-M and PND for austere altitude such as those included in this ECS-test are attainable to aerial accident couples. In the Netherlands, costs of PGT-M and prenatal testing are covered by accustomed bloom insurance.
Figure 1 additionally depicts the abstraction design. We acclimated a alloyed methods longitudinal architecture with four abstraction time credibility (T0–T3), with couples and GPs as abstraction participants. GPs were asked to appraise anniversary alone pre-test counselling at T1. At T3 they were arrive to booty allotment in semi-structured
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